BDBM414395 US10435369, Example 282::US10435369, Example 283

SMILES NS(=O)(=O)N1CCC(CNC(=O)[C@@H]2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1

InChI Key InChIKey=RZPHHKFIKRNNEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414395   

TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM414395(US10435369, Example 282 | US10435369, Example 283)
Affinity DataIC50: 6nMAssay Description:Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM414395(US10435369, Example 282 | US10435369, Example 283)
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent