BDBM414407 (S)-1-(2-cyanoethyl)-N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-yl)-5-oxopyrrolidine-3-carboxamide::US10435369, Example 294

SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@@H](NC(=O)[C@@H]3CN(CCC#N)C(=O)C3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=RGBQAUAZQBXYOA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 414407   

TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM414407((S)-1-(2-cyanoethyl)-N-((3R,3aS,9bS)-9b-((4-fluoro...)
Affinity DataIC50: 4nMAssay Description:Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent