BDBM414503 N-Ethyl-N-{2-[4-(1-hydroxy- 1-methylethyl)-5-methyl-1,3- oxazol-2-yl]ethyl}-2-(1H- pyrazol-1-yl)benzamide::US10435398, Example 17

SMILES CCN(CCc1nc(c(C)o1)C(C)(C)O)C(=O)c1ccccc1-n1cccn1

InChI Key InChIKey=CWVPLMLFHSISTO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414503   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414503(N-Ethyl-N-{2-[4-(1-hydroxy- 1-methylethyl)-5-methy...)
Affinity DataIC50: 292nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414503(N-Ethyl-N-{2-[4-(1-hydroxy- 1-methylethyl)-5-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent