BDBM414508 N-{2-[4-(1-Hydroxy-1-methylethyl)-5-methyl-1,3-oxazol-2-yl]ethyl}-N-propyl-2-(2H-1,2,3-triazol-2-yl)benzamide::US10435398, Example 22

SMILES CCCN(CCc1nc(C(=O)OCC)c(C)o1)C(=O)c1ccccc1-n1nccn1

InChI Key InChIKey=SMHPZMGAXTZNND-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414508   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414508(N-{2-[4-(1-Hydroxy-1-methylethyl)-5-methyl-1,3-oxa...)
Affinity DataIC50: 19nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414508(N-{2-[4-(1-Hydroxy-1-methylethyl)-5-methyl-1,3-oxa...)
Affinity DataIC50: 2.37E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent