BDBM414534 US10435400, Compound Z-32

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(C)=O)c(n1)-c1cnc2n(C)ccc2c1

InChI Key InChIKey=BXILVRXAZNCCSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414534   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM414534(US10435400, Compound Z-32)
Affinity DataIC50:  4nMAssay Description:The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM414534(US10435400, Compound Z-32)
Affinity DataIC50:  2nMAssay Description:The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent