BDBM415495 US10428074, Example 99

SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12

InChI Key InChIKey=NFXSQEWDYUCEGU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 415495   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM415495(US10428074, Example 99)
Affinity DataIC50: 0.300nMAssay Description:JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM415495(US10428074, Example 99)
Affinity DataIC50: 5nMAssay Description:JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM415495(US10428074, Example 99)
Affinity DataIC50: 110nMAssay Description:JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent