BDBM415673 4-Amino-2-[6-fluoro-1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-methyl-5-[3-(1H-tetrazol-5-yl)phenyl]-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10428076, Example 249B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1cccc(c1)-c1nn[nH]n1

InChI Key InChIKey=KZAUJCRAYYYKNE-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 415673   

TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM415673(US10428076, Example 249B | 4-Amino-2-[6-fluoro-1-(...)
Affinity DataKi:  0.0680nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
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Date in BDB:
8/17/2020
Entry Details
US Patent