BDBM4158 (2S,4S)-N-tert-butyl-4-chloro-1-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2,4-dimethylphenyl)formamido]-4-(2-methylphenyl)butanoyl]pyrrolidine-2-carboxamide::(3-Hydroxy-2,4-dimethylbenzoyl)-(2(S)-hydroxy-3(S)-amino-4-o-tolylbutanoyl)-4(S)-Cl-Pro-NH-t-Bu::AHPBA deriv. 43::CHEMBL324285

SMILES Cc1ccccc1C[C@H](NC(=O)c1ccc(C)c(O)c1C)[C@H](O)C(=O)N1C[C@@H](Cl)C[C@H]1C(=O)NC(C)(C)C

InChI Key InChIKey=ACDGIJFDLYOONA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4158   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM4158((2S,4S)-N-tert-butyl-4-chloro-1-[(2S,3S)-2-hydroxy...)
Affinity DataIC50: 49.9nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sankyo

LigandPNGBDBM4158((2S,4S)-N-tert-butyl-4-chloro-1-[(2S,3S)-2-hydroxy...)
Affinity DataIC50: 49.9nMAssay Description:The inhibitory activities of the compounds toward HIV-1 PR were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2005
Entry Details Article
PubMed