BDBM415946 US10442810, Example 112::US11591338, Example 112

SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C(C)=O)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12

InChI Key InChIKey=KOXFILDWTLYJLI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 415946   

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM415946(US10442810, Example 112 | US11591338, Example 112)
Affinity DataIC50: 5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM415946(US10442810, Example 112 | US11591338, Example 112)
Affinity DataIC50: 5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM415946(US10442810, Example 112 | US11591338, Example 112)
Affinity DataIC50: 7.5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM415946(US10442810, Example 112 | US11591338, Example 112)
Affinity DataIC50: 55nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM415946(US10442810, Example 112 | US11591338, Example 112)
Affinity DataIC50: 100nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM415946(US10442810, Example 112 | US11591338, Example 112)
Affinity DataIC50: 100nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent