BDBM416694 2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-acetamide::US10323028, Example 27::US10323028, Example 28

SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)C1

InChI Key InChIKey=JWANLTKYUMFDIQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 416694   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM416694(US10323028, Example 27 | US10323028, Example 28 | ...)
Affinity DataIC50: 149nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM416694(US10323028, Example 27 | US10323028, Example 28 | ...)
Affinity DataIC50: 195nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent