BDBM417359 US10457654, Example 218

SMILES CN(C)[C@H]1C[C@@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=SIZNYQOMIBVCNQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417359   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM417359(US10457654, Example 218)
Affinity DataIC50: 1.60nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM417359(US10457654, Example 218)
Affinity DataIC50: 20.9nMAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent