BDBM418158 2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-oxo- 2,3-dihydro-1H-isoindol-2-yl}-N- [(1S,2S)-1-(3-fluoro-5- methoxyphenyl)-2- hydroxybutyl]acetamide::US10457669, Example 907::US11001575, Example 907

SMILES CC[C@H](O)[C@@H](NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC)ncc1Cl)c1cc(F)cc(OC)c1

InChI Key InChIKey=QVIOYHQCZUFRHB-URXFXBBRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418158   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418158(2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...)
Affinity DataIC50:  2nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418158(2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...)
Affinity DataIC50:  2nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent