BDBM418548 8-(1-Difluoromethyl-1H- pyrazol-4-yl)-1-(3-fluoro-5- methoxypyridin-4-yl)-7- methoxy-3-methyl-1,3- dihydroimidazo[4,5-c] quinolin-2-one::US10457677, Example 143::US10975075, Example 143::US11608338, Example 143

SMILES COc1cncc(F)c1-n1c2c(cnc3cc(OC)c(cc23)-c2cnn(c2)C(F)F)n(C)c1=O

InChI Key InChIKey=RWJZFHKYUHCIBT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418548   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418548(8-(1-Difluoromethyl-1H- pyrazol-4-yl)-1-(3-fluoro-...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418548(8-(1-Difluoromethyl-1H- pyrazol-4-yl)-1-(3-fluoro-...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418548(8-(1-Difluoromethyl-1H- pyrazol-4-yl)-1-(3-fluoro-...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent