BDBM418552 1-(3-Difluoromethoxy-5- fluoropyridin-4-yl)-8-(1,3- dimethyl-1H-pyrazol-4-yl)-7- methoxy-3-methyl-1,3- dihydroimidazo[4,5-c]- quinolin-2-one::US10457677, Example 147::US10975075, Example 147::US11608338, Example 147

SMILES COc1cc2ncc3n(C)c(=O)n(-c4c(F)cncc4OC(F)F)c3c2cc1-c1cn(C)nc1C

InChI Key InChIKey=VURXWRPFWBRPRD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418552   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418552(1-(3-Difluoromethoxy-5- fluoropyridin-4-yl)-8-(1,3...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418552(1-(3-Difluoromethoxy-5- fluoropyridin-4-yl)-8-(1,3...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418552(1-(3-Difluoromethoxy-5- fluoropyridin-4-yl)-8-(1,3...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent