BDBM4187 1,6-naphthyridin-2(1H)-one deriv. 7t::3-(2,6-Dichlorophenyl)-1-methyl-7-[[4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]amino]-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-1-methyl-7-({4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)-1,2-dihydro-1,6-naphthyridin-2-one

SMILES CN1CCN(CCCOc2ccc(Nc3cc4n(C)c(=O)c(cc4cn3)-c3c(Cl)cccc3Cl)cc2)CC1

InChI Key InChIKey=PQZDDSNPXGLODE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4187   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM4187(3-(2,6-dichlorophenyl)-1-methyl-7-({4-[3-(4-methyl...)
Affinity DataIC50: 28nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM4187(3-(2,6-dichlorophenyl)-1-methyl-7-({4-[3-(4-methyl...)
Affinity DataIC50: 120nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM4187(3-(2,6-dichlorophenyl)-1-methyl-7-({4-[3-(4-methyl...)
Affinity DataIC50: 900nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed