BDBM419873 US10464927, Compound I-21

SMILES CC(C)n1c(cc2cc(ccc12)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C2CCC2)ncc1F)C1CCCC1

InChI Key InChIKey=RQUNQBYFMRWEJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419873   

TargetCyclin-dependent kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology

US Patent
LigandPNGBDBM419873(US10464927, Compound I-21)
Affinity DataIC50: 20nMAssay Description:CDK4: The test compound was dissolved in DMSO and diluted with a kinase buffer solution (20 mM HEPES-pH 7.5, 0.01% Triton X-100, 10 mM MgCl2, 2 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Shanghai Xunhe Pharmaceutical Technology

US Patent
LigandPNGBDBM419873(US10464927, Compound I-21)
Affinity DataIC50: 60nMAssay Description:CDK6: The test compound was dissolved in DMSO and diluted with a kinase buffer solution (20 mM HEPES-pH 7.5, 0.01% Triton X-100, 10 mM MgCl2, 2 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent