BDBM419951 US10472364, Compound 37::US10472364, Compound 38::US10570167, Cpd. # 38::US11034715, Cpd. # 38::US11208414, Cpd. # 38

SMILES CCOC(=O)C(Cc1ccc(OC(F)(F)F)cc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O

InChI Key InChIKey=IVDDSYQYYSRCTJ-IDWGQNBZSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 419951   

Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  718nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  686nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  598nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  1.49E+3nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  718nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  686nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  1.49E+3nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  686nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  598nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  1.49E+3nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  718nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  686nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  598nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419951(US10472364, Compound 37 | US10472364, Compound 38 ...)
Affinity DataIC50:  718nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent