BDBM421525 N-(1-Methylcyclopropyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)indole-6-sulfonamide::US10508086, Example 115::US10995073, Example 115::US20230303556, Example 115 from WO2016/097749

SMILES Cc1nnc(s1)-n1ccc2ccc(cc12)S(=O)(=O)NC1(C)CC1

InChI Key InChIKey=CSKMWAVAGSVLMK-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 421525   

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421525(US10508086, Example 115 | N-(1-Methylcyclopropyl)-...)
Affinity DataEC50:  2.32E+3nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421525(US10508086, Example 115 | N-(1-Methylcyclopropyl)-...)
Affinity DataEC50:  2.32E+3nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421525(US10508086, Example 115 | N-(1-Methylcyclopropyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent