BDBM421846 (R)-7-(2-(4-(4-(1-Methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-2-(3-(2-methylpyridin-4-yl)-1H-indazol-5-yl)-2,7-diazaspiro[4.4]nonan-1-one::US10493060, Example 9::US10525036, Example 9

SMILES Cc1cc(-c2n[nH]c3ccc(N4CC[C@@]5(CCN(CC(=O)N6CC=C(c7ccc(-c8ncn(C)n8)cc7)CC6)C5)C4=O)cc23)ccn1

InChI Key InChIKey=QONXOGNUFYADHH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 421846   

TargetMitogen-activated protein kinase 1(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 421846BDBM421846(US10493060, Example 9 | US10525036, Example 9 | (R...)
Affinity DataIC50: 50nMAssay Description:Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 421846BDBM421846(US10493060, Example 9 | US10525036, Example 9 | (R...)
Affinity DataIC50: 50nMAssay Description:Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 421846BDBM421846(US10493060, Example 9 | US10525036, Example 9 | (R...)
Affinity DataIC50: 150nMAssay Description:Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 421846BDBM421846(US10493060, Example 9 | US10525036, Example 9 | (R...)
Affinity DataIC50: 150nMAssay Description:Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent