BDBM422353 US10508099, Compound 1084::US10556885, Compound 1084::US11174244, Compound 1084::US11673881, Compound 1084

SMILES COC(=O)[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1

InChI Key InChIKey=QXGWFGOTMGPLKW-UHFFFAOYSA-N

Data  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 422353   

LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  1.70nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  1.70nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  1.70nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  1.70nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  40nMAssay Description:The GSK3B kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divisio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  40nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  40nMAssay Description:GSK3B: This is a non-radioactive assay using fluorescence resonance energy transfer (FRET) between coumarin and fluorescein to detect kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  40nMAssay Description:Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetProto-oncogene Wnt-1(Human)
Samumed

US Patent
LigandPNGBDBM422353(US10556885, Compound 1084 | US10508099, Compound 1...)
Affinity DataEC50:  3.41E+3nMAssay Description:SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent