BDBM42273 4,5-Dichloro-isothiazole-3-carboxylic acid 1-[(thiophen-2-ylmethyl)-carbamoyl]-ethyl ester::4,5-dichloro-3-isothiazolecarboxylic acid [1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] ester::4,5-dichloroisothiazole-3-carboxylic acid [2-keto-1-methyl-2-(2-thenylamino)ethyl] ester::MLS000073961::SMR000006588::[1-oxidanylidene-1-(thiophen-2-ylmethylamino)propan-2-yl] 4,5-bis(chloranyl)-1,2-thiazole-3-carboxylate::[1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] 4,5-dichloro-1,2-thiazole-3-carboxylate::cid_647824

SMILES FCCN1N=CC(=C1)C1=CC=C(C=N1)/C=C/C=1C=NC(=NC1)N1C[C@@H](N(CC1)C1=NC=CC=N1)COC

InChI Key InChIKey=CKTHRALBLNYWDD-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 42273   

TargetAlpha-synuclein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 42273BDBM42273((R,E)-5-(2-(6-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)p...)
Affinity DataKi:  0.620nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent

TargetAmyloid-beta precursor protein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 42273BDBM42273((R,E)-5-(2-(6-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)p...)
Affinity DataKi:  1.20E+3nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent