BDBM422804 US10508107, Example 10::US11312711, Example 10

SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccc(nc1)C#N

InChI Key InChIKey=MQFBCPOULYPWAQ-UHFFFAOYSA-N

Data  2 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 422804   

TargetTrace amine-associated receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422804(US10508107, Example 10 | US11312711, Example 10)
Affinity DataEC50:  184nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR1 were amplified from genomic DNA essentially as described by Lindemann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetTrace amine-associated receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422804(US10508107, Example 10 | US11312711, Example 10)
Affinity DataEC50:  184nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR 1 were amplified from genomic DNA essentially as described by Lindeman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422804(US10508107, Example 10 | US11312711, Example 10)
Affinity DataKi:  1.13E+4nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422804(US10508107, Example 10 | US11312711, Example 10)
Affinity DataKi:  1.13E+4nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422804(US10508107, Example 10 | US11312711, Example 10)
Affinity DataIC50: 3.17E+4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422804(US10508107, Example 10 | US11312711, Example 10)
Affinity DataIC50: 3.17E+4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent