BDBM423172 4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isopropenyl-4-pyridyl]amino]-N-[(2S)-2-hydroxypropyl]pyridine-3-carboxamide::US10501436, Compound 23a

SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(nc(N)c1C(C)=C)-c1cc(Cl)ccc1F

InChI Key InChIKey=OAYQAXXBPMOPLN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 423172   

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM423172(US10501436, Compound 23a | 4-[[2-amino-6-(5-chloro...)
Affinity DataIC50: 16.9nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM423172(US10501436, Compound 23a | 4-[[2-amino-6-(5-chloro...)
Affinity DataIC50: 33.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM423172(US10501436, Compound 23a | 4-[[2-amino-6-(5-chloro...)
Affinity DataIC50: 5.67E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM423172(US10501436, Compound 23a | 4-[[2-amino-6-(5-chloro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM423172(US10501436, Compound 23a | 4-[[2-amino-6-(5-chloro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM423172(US10501436, Compound 23a | 4-[[2-amino-6-(5-chloro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent