BDBM423456 US10501467, Example 62

SMILES CC(N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O)C(C)(C)N

InChI Key InChIKey=UFDIRFJWPGCILC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423456   

TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM423456(US10501467, Example 62)
Affinity DataIC50: 1.00E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM423456(US10501467, Example 62)
Affinity DataIC50: 7.20E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Beigene

US Patent
LigandPNGBDBM423456(US10501467, Example 62)
Affinity DataIC50: 1.80E+4nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM423456(US10501467, Example 62)
Affinity DataIC50: 3.80E+6nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent