BDBM423652 US10508120, Compound I-107::US10577373, Compound I-107::US11046698, Compound I-107

SMILES CNc1cc(Nc2cccn(-c3ccc(F)cc3)c2=O)nc2c(cnn12)C(=O)NC1CC1

InChI Key InChIKey=ZXEHQNGMBCCZMT-UHFFFAOYSA-N

Data  2 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 423652   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423652(US10508120, Compound I-107 | US10577373, Compound ...)
Affinity DataKd:  0.0630nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423652(US10508120, Compound I-107 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423652(US10508120, Compound I-107 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423652(US10508120, Compound I-107 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423652(US10508120, Compound I-107 | US10577373, Compound ...)
Affinity DataIC50: 45nMAssay Description:Inhibition of TYK2 in human PBMC cells assessed as IL-12 induced phosphorylation of STAT4 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423652(US10508120, Compound I-107 | US10577373, Compound ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D (unknown origin) assessed as enzyme activity by transcreener AMP2/GMP2 FP PDE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed