BDBM424388 US10508120, Compound I-843::US10508120, Compound I-973::US10577373, Compound I-973::US11046698, Compound I-973::US11414431, Compound I-270

SMILES CNc1cc(Nc2cccn(-c3ccc(C)nc3)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC

InChI Key InChIKey=NFDQVQBRZHAIKE-UHFFFAOYSA-N

Data  3 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 424388   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd:  0.0340nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of TYK2 in human PBMC cells assessed as IL-12 induced phosphorylation of STAT4 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataKd:  5.5nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of JAK in human PBMC cells assessed as GM-CSF-induced phosphorylation of STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424388(US10508120, Compound I-973 | US10508120, Compound ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of JAK in human PBMC cells assessed as IL-12-induced phosphorylation of STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed