BDBM424915 US10517849, Compound 11::US11013718, Compound 11::US11547695, Compound 11

SMILES CC\C(=C/c1ccccc1)[C@@H]1C[C@H]1NC1CC2(C1)CCN(CCO)CC2

InChI Key InChIKey=WNPFGIFEKPKWMQ-ISHKIFBASA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 424915   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424915(US10517849, Compound 11 | US11013718, Compound 11 ...)
Affinity DataIC50: <100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424915(US10517849, Compound 11 | US11013718, Compound 11 ...)
Affinity DataEC50:  5nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424915(US10517849, Compound 11 | US11013718, Compound 11 ...)
Affinity DataIC50: <100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424915(US10517849, Compound 11 | US11013718, Compound 11 ...)
Affinity DataIC50: <100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424915(US10517849, Compound 11 | US11013718, Compound 11 ...)
Affinity DataIC50: <3nMAssay Description:Inhibition of recombinant N-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli expression system using ART-K(Me1)-QTARKSTGGKAPRK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed