BDBM425889 N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]phenyl}-1H- benzimidazole-6-carboxamide::US10512634, Example 207

SMILES CN1CCN(Cc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(=O)NO)CC1

InChI Key InChIKey=CVLLNANRQSBRJP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 425889   

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425889(N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]p...)
Affinity DataIC50: 7nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425889(N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]p...)
Affinity DataIC50: 7nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
Kancera

US Patent
LigandPNGBDBM425889(N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]p...)
Affinity DataIC50: 250nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Kancera

US Patent
LigandPNGBDBM425889(N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]p...)
Affinity DataIC50: 700nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Kancera

US Patent
LigandPNGBDBM425889(N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]p...)
Affinity DataIC50: 1.80E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
Kancera

US Patent
LigandPNGBDBM425889(N-hydroxy-2-{4-[(4- methylpiperazin-1- yl)methyl]p...)
Affinity DataIC50: 7.80E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent