BDBM426162 5-[8-(Dimethylamino)-2-(4-fluorophenyl)imidazo[1,2-a]pyrazin-3-yl]-::US10513523, Example 101

SMILES CN(C)c1nccn2c(-c3ccc4[nH]c(=O)[nH]c4c3)c(-c3ccc(F)cc3)nc12

InChI Key InChIKey=LRXFPEGELUOGKN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 426162   

TargetGlutamate receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 426162BDBM426162(US10513523, Example 101 | 5-[8-(Dimethylamino)-2-(...)
Affinity DataIC50: 0.5nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2020
Entry Details
US Patent