BDBM426335 US10526325, Compound A12

SMILES CC1CN(Cc2cnn(c12)-c1ccc(F)cc1)C(=O)[C@@](C)(O)C(F)(F)F

InChI Key InChIKey=WZBWLIMRPORCNI-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426335   

LigandPNGBDBM426335(US10526325, Compound A12)
Affinity DataKd: <300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

LigandPNGBDBM426335(US10526325, Compound A12)
Affinity DataIC50: 300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter. In general titrations were performed by titrating the protein (50 μM) to the te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent