BDBM426353 US10526325, Compound A29::US10829489, Compound A29::US11261185, Example 29
SMILES C[C@H]1CN(Cc2cn[nH]c12)C(=O)[C@@](C)(O)C(F)(F)F
InChI Key InChIKey=NCGPBXOHHKQISM-QUBYGPBYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 426353
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataIC50: 1.65E+3nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter. In general titrations were performed by titrating the protein (50 μM) to the te...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataKd: 1.65E+3nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataIC50: 1.65E+3nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataKd: 1.65E+3nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataIC50: 1.65E+3nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair