BDBM426386 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-(imidazo[1,2-a]pyrazin-8-ylthio)-2-methylpiperidin-1-yl)methanone::US10526336, Example 5

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Sc1nccn2ccnc12

InChI Key InChIKey=YRLBEVPYAPWLKJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426386   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426386(US10526336, Example 5 | (2-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 10.3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426386(US10526336, Example 5 | (2-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 2.39E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent