BDBM426390 1-(2-((2R,5R)-2-methyl-5-((2- methylimidazo[1,2-alpha]pyrazin-8- yl)oxy)piperidine-1- carbonyl)phenyl)cyclopropanecarbonitrile::US10526336, Example 9

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)Oc1nccn2cc(C)nc12

InChI Key InChIKey=SXVFMYAMZHNWPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426390   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426390(US10526336, Example 9 | 1-(2-((2R,5R)-2-methyl-5-(...)
Affinity DataIC50: 13.2nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426390(US10526336, Example 9 | 1-(2-((2R,5R)-2-methyl-5-(...)
Affinity DataIC50: 6.70E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent