BDBM426410 (2-(2H-1,2,3-triazol-2- yl)thiophen-3-yl)((2R,5R)- 5-((3-chloroimidazo[1,2-alpha] pyrazin-8-yl)oxy)-2- methylpiperidin-1-yl)methanone::US10526336, Example 29

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)Oc1nccn2c(Cl)cnc12

InChI Key InChIKey=KGTBEKFEEFNSRO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426410   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426410(US10526336, Example 29 | (2-(2H-1,2,3-triazol-2- y...)
Affinity DataIC50: 14.3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426410(US10526336, Example 29 | (2-(2H-1,2,3-triazol-2- y...)
Affinity DataIC50: 2.56E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent