BDBM426425 (2-(2H-tetrazol-2-yl)phenyl)((2R,5R)-5- ((3-(difluoromethyl)imidazo[1,2-alpha] pyrazin-8-yl)oxy)-2-methylpiperidin- 1-yl)methanone::US10526336, Example 44

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)Oc1nccn2c(cnc12)C(F)F

InChI Key InChIKey=GQGYSGKNILVDGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426425   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426425(US10526336, Example 44 | (2-(2H-tetrazol-2-yl)phen...)
Affinity DataIC50: 9.60nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426425(US10526336, Example 44 | (2-(2H-tetrazol-2-yl)phen...)
Affinity DataIC50: 2.06E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent