BDBM426429 US10526336, Example 48::methyl 2-((2R,5R)-5-((3- (difluoromethyl)imidazo[1,2-alpha]pyrazin-8- yl)oxy)-2-methylpiperidine-1- carbonyl)benzoate

SMILES COC(=O)c1nccnc1C(=O)N1C[C@@H](CC[C@H]1C)Oc1nccn2c(cnc12)C(F)F

InChI Key InChIKey=ADMNEWANDIGMEI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426429   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426429(US10526336, Example 48 | methyl 2-((2R,5R)-5-((3- ...)
Affinity DataIC50: 24.9nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426429(US10526336, Example 48 | methyl 2-((2R,5R)-5-((3- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent