BDBM426433 (2-(1H-pyrazol-1-yl)pyridin-3- yl)((2R,5R)-5-((3- (difluoromethyl)imidazo[1,2-alpha]pyrazin-8- yl)oxy)-2-methylpiperidin-1-yl)methanone::US10526336, Example 52

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-n1cccn1)Oc1nccn2c(cnc12)C(F)F

InChI Key InChIKey=ABZHMQSVRFLUKD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426433   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426433(US10526336, Example 52 | (2-(1H-pyrazol-1-yl)pyrid...)
Affinity DataIC50: 15.8nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426433(US10526336, Example 52 | (2-(1H-pyrazol-1-yl)pyrid...)
Affinity DataIC50: 1.57E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent