BDBM426439 (2-(2H-1,2,3-triazol-2-yl)thiophen-3-yl)((2R,5R)-2-methyl-5-((3-(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl)oxy)piperidin-1-yl)methanone::US10526336, Example 58

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)Oc1nccn2c(cnc12)C(F)(F)F

InChI Key InChIKey=YXSCINZYKDOOTA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426439   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426439(US10526336, Example 58 | (2-(2H-1,2,3-triazol-2-yl...)
Affinity DataIC50: 20.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426439(US10526336, Example 58 | (2-(2H-1,2,3-triazol-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent