BDBM426441 (2-(2H-tetrazol-2- yl)phenyl)((2R,5R)-2- methyl-5-((3- (trifluoromethyl)imidazo [1,2-alpha]pyrazin-8- yl)oxy)piperidin-1- yl)methanone::US10526336, Example 60

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)Oc1nccn2c(cnc12)C(F)(F)F

InChI Key InChIKey=MTTWBUAOCWCXGN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426441   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426441(US10526336, Example 60 | (2-(2H-tetrazol-2- yl)phe...)
Affinity DataIC50: 19nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426441(US10526336, Example 60 | (2-(2H-tetrazol-2- yl)phe...)
Affinity DataIC50: 8.62E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent