BDBM426446 (2-(1H-pyrazol-1- yl)pyridin-3-yl) ((2R,5R)-2-methyl-5-((3- (trifluoromethyl)imidazo [1,2-alpha]pyrazin-8- yl)oxy)piperidin-1- yl)methanone::US10526336, Example 65

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-n1cccn1)Oc1nccn2c(cnc12)C(F)(F)F

InChI Key InChIKey=XKLXYPZJASGHGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426446   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426446(US10526336, Example 65 | (2-(1H-pyrazol-1- yl)pyri...)
Affinity DataIC50: 24nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426446(US10526336, Example 65 | (2-(1H-pyrazol-1- yl)pyri...)
Affinity DataIC50: 9.33E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent