BDBM426452 (4-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-2-methyl-5-(pyrazolo[1,5- alpha]pyrazin-4-yloxy)piperidin-1- yl)methanone::US10526336, Example 71::US10526336, Example 74

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)Oc1nccn2ccnc12

InChI Key InChIKey=RCKFRNYPWUJDTQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 426452   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426452(US10526336, Example 71 | US10526336, Example 74 | ...)
Affinity DataIC50: 16nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426452(US10526336, Example 71 | US10526336, Example 74 | ...)
Affinity DataIC50: 34.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426452(US10526336, Example 71 | US10526336, Example 74 | ...)
Affinity DataIC50: 7.28E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426452(US10526336, Example 71 | US10526336, Example 74 | ...)
Affinity DataIC50: 7.50E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent