BDBM426477 (2-ethoxyphenyl)((2R,5R)- 2-methyl-5- (oxazolo[5,4-b]pyridin- 7-yloxy)piperidin-1- yl)methanone::US10526336, Example 94

SMILES CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)Oc1ccnc2ocnc12

InChI Key InChIKey=RYYMOGIVOKFLFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426477   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426477(US10526336, Example 94 | (2-ethoxyphenyl)((2R,5R)-...)
Affinity DataIC50: 24.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426477(US10526336, Example 94 | (2-ethoxyphenyl)((2R,5R)-...)
Affinity DataIC50: 2.16E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent