BDBM426489 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-2-methyl-5-((2-methyl-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)oxy)piperidin-1-yl)methanone::US10526336, Example 104::US10526336, Example 105

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1nccc2nc(C)nn12

InChI Key InChIKey=CYSKASVYURZNFQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 426489   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426489(US10526336, Example 104 | (2-(2H-1,2,3-triazol-2-y...)
Affinity DataIC50: 27.6nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426489(US10526336, Example 104 | (2-(2H-1,2,3-triazol-2-y...)
Affinity DataIC50: 60nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426489(US10526336, Example 104 | (2-(2H-1,2,3-triazol-2-y...)
Affinity DataIC50: 7.26E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426489(US10526336, Example 104 | (2-(2H-1,2,3-triazol-2-y...)
Affinity DataIC50: 9.14E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent