BDBM426551 4-[6-(4-aminopiperidin-1-yl)-3-{1- methyl-1H-pyrrolo[2,3-b]pyridin- 5-yl}pyrazin-2-yl]-2- fluorobenzonitrile::US10543198, Example 55::US10864202, Example 55

SMILES Cn1ccc2cc(cnc12)-c1ncc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1

InChI Key InChIKey=VJUCSJOZTQSPLL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426551   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM426551(US10543198, Example 55 | 4-[6-(4-aminopiperidin-1-...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM426551(US10543198, Example 55 | 4-[6-(4-aminopiperidin-1-...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent