BDBM427089 (3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-3-(4-chlorophenyl)-4-fluoro-6-[2-hydroxy-1-(piperazin-1-yl)propan-2-yl]-3-{[1-(hydroxymethyl)cyclopropyl]methoxy}-2,3-dihydro-1H-isoindol-1-one::US10544132, Example 44::US10981898, Example 44

SMILES C[C@](O)(CN1CCNCC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=NTYHQRPYZXGTGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427089   

LigandPNGBDBM427089((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)
Affinity DataIC50: 5.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427089((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)
Affinity DataIC50: 5.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent