BDBM427147 (3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[1-hydroxy-1-(oxan-4-yl)ethyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]propanoic Acid::US10544132, Example 88::US10981898, Example 88

SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@@](C)(O)C1CCOCC1)c1ccc(Cl)cc1

InChI Key InChIKey=AVDHVIXZENQIRS-HOSFBAFGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427147   

LigandPNGBDBM427147((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)
Affinity DataIC50:  0.790nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427147((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)
Affinity DataIC50:  0.790nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent