BDBM427156 4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-1-(1-methyl-1H-imidazol-4-yl)propyl]-3-oxo-1-[(3S)-oxolan-3-yloxy]-2,3-dihydro-1H-isoindol-2-yl]methyl}benzonitrile::US10544132, Example 96::US10981898, Example 96

SMILES CC[C@@](O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=CDUKUNZREUVQKN-FRJUPVQCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427156   

TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM427156(4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...)
Affinity DataIC50:  0.640nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM427156(4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...)
Affinity DataIC50:  0.640nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent