BDBM427741 US10544143, Example 174::US10730877, Example 199::US11053244, Example 199

SMILES COc1cc(cn2ncnc12)-c1[nH]c2ccc(nc2c1C(C)C)C1CCC(CC1)N1CCCC1

InChI Key InChIKey=JDGZEKNWRDRRRG-UHFFFAOYSA-N

Data  27 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 427741   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  4.30nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.19E+3nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.47E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  4.30nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  37nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.47E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  3.10nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  19nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.11E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  0.800nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  4.30nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  530nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  0.160nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  6.40nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.19E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  4.30nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  37nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.47E+3nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  3.10nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  19nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.11E+3nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  0.800nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  4.30nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  530nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  0.160nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  6.40nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

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TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent

LigandBDBM427741(US10544143, Example 174 | US10730877, Example 199 ...)Copy SMILESCopy InChI

Affinity DataIC50:  37nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

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