BDBM428643 US10544146, Ex. 40

SMILES CC(=O)NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O

InChI Key InChIKey=WVZOCYGRXONJLX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 428643   

TargetBeta-lactamase(Escherichia coli)
Fedora Pharmaceuticals

US Patent
LigandPNGBDBM428643(US10544146, Ex. 40)
Affinity DataIC50: 8nMAssay Description:he inhibitory activities of present compounds against various enzymes were measured by spectrophotometric assay using 490 nM and using nitrocefin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetBeta-lactamase TEM(Escherichia coli)
Fedora Pharmaceuticals

US Patent
LigandPNGBDBM428643(US10544146, Ex. 40)
Affinity DataIC50: 52nMAssay Description:he inhibitory activities of present compounds against various enzymes were measured by spectrophotometric assay using 490 nM and using nitrocefin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetCarbapenem-hydrolyzing beta-lactamase KPC(Klebsiella oxytoca)
Fedora Pharmaceuticals

US Patent
LigandPNGBDBM428643(US10544146, Ex. 40)
Affinity DataIC50: 91nMAssay Description:he inhibitory activities of present compounds against various enzymes were measured by spectrophotometric assay using 490 nM and using nitrocefin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli)
Fedora Pharmaceuticals

US Patent
LigandPNGBDBM428643(US10544146, Ex. 40)
Affinity DataIC50: 327nMAssay Description:he inhibitory activities of present compounds against various enzymes were measured by spectrophotometric assay using 490 nM and using nitrocefin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent