BDBM428644 (R or S)-5-[9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl]-3-methyl-3-(2- methylpropyl)-1,3-dihydro- 2H-indol-2-one::US10544147, Compound 1-1::US10544147, Compound 1-12::US10544147, Compound 1-2

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C(C)(CC(C)C)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=PBHZRZFWVRFZSW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 428644   

LigandPNGBDBM428644(US10544147, Compound 1-1 | US10544147, Compound 1-...)
Affinity DataIC50: 4nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

LigandPNGBDBM428644(US10544147, Compound 1-1 | US10544147, Compound 1-...)
Affinity DataIC50: 9nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

LigandPNGBDBM428644(US10544147, Compound 1-1 | US10544147, Compound 1-...)
Affinity DataIC50: 121nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent